• Stroke also known as a cerebrovascular accident or brain att

  2024-08-02

  

  Stroke, also known as a cerebrovascular accident or rosavin attack, is one of the leading causes of death and disability worldwide (Haley et al., 2017; Hankey, 2017; Lie et al., 2017). According to the data released by the World Health Organization (WHO), stroke occurs every 5 s worldwide (WHO, 201

• The activity of an enzyme may be regulated allosterically

  2024-08-02

  

  The activity of an enzyme may be regulated allosterically as well as transcriptionally. We have consistently studied REMS deprivation (REMSD) associated NA mediated allosteric regulation of Na-K ATPase activity in neurons and glia in vivo and in vitro (Amar and Mallick, 2015; Amar et al., 2016; Bask

• In the pituitary of R quelen mRNA

  2024-08-01

  

  In the pituitary of R. quelen mRNA levels of cyp19a1b were found to be higher in males than females, suggesting a sex-specific function, and perhaps a local action to regulate gonadotropins or other pituitary hormone secretion (Olivereau and Callard, 1985; Zhang et al., 2014). Interestingly, the hig

• The use of FTAI can overcome

  2024-08-01

  

  The use of FTAI can overcome the negative impact of low estrus detection efficiency, but implies effective synchrony of luteal function as well as synchronous growth and ovulation of a viable Nucleozin follicle. Pregnancy rates obtained with FTAI may be comparable or better than those obtained afte

• 94 7 Plant defensins are cysteine rich cationic peptides of

  2024-08-01

  

  Plant defensins are cysteine-rich cationic peptides of 5–8 kDa whose mature domain comprises 45 to 54 amino 94 7 residues, with an isoelectric point around 9. The global fold of plant defensins consists of a cysteine-stabilized motif (CSα/β) made up of an α-helix and a triple-stranded β-sheet stabi

• A has been reported to decrease insulin receptors and

  2024-08-01

  

  Aβ has been reported to decrease insulin receptors and impair insulin signaling in neurons, preventing phosphorylation of Akt and glycogen synthase kinase 3β (GSK-3β), downstream of insulin signaling, and to increase phosphorylation of tau protein causing neurofibrillary tangles (Tokutake et al., 20

• Aerobic exercise plays an important role in the regulation o

  2024-08-01

  

  Aerobic exercise plays an important role in the regulation of Danoprevir metabolism in the skeletal muscle. It is also associated with increases in AMPK and GLUT4 levels, resulting in the improvement of the glucose uptake signaling pathway [17,18]. Recently, it has been shown that exercise markedly

• br Conflicts of interest br Funding br

  2024-08-01

  

  Conflicts of interest Funding Introduction Brassicaceae is an economically important family of plants containing rapeseed, cabbage, broccoli, brussels, radish and mustard. Among them rapeseed plays a crucial role, because of its application in food and also in fuel industry. According to th

• br Concluding remarks Enhanced membrane binding upon calcium

  2024-08-01

  

  Concluding remarks Enhanced membrane binding upon calcium stimulation in DS2 suggests a pre-requisite step that involves a conformational change in LOX. This might facilitate it to tether to the membrane and regulate enzyme activity. The calcium binding loops and the putative active site entranc

• SZL P1-41 The decreased AR mediated response has been attrib

  2024-08-01

  

  The decreased βAR-mediated response has been attributed to different mechanisms, including an attenuation of PKA activation, an impaired generation of cyclic AMP, a reduced receptor density, and a less efficient coupling to adenylyl-cyclase [10]. However, currently there is no single molecular or ce

• br Adiponectin in prostate cancer PC was

  2024-08-01

  

  Adiponectin in prostate cancer PC was documented as the leading type of malignancy in males in the US with respect to both the estimated number of cases (22,800) and deaths (27,540) (Siegel et al., 2016). Studies have reported an association between low APN levels and the progression of PC (Micha

• Adiponectin belongs to the CTRP

  2024-08-01

  

  Adiponectin belongs to the CTRP (C1q/TNF-related protein) superfamily. Except for adiponectin, 15 additional members have been identified (CTRP1-15) (Schaffler and Buechler, 2012). Of all the CTRPs, CTRP9 has the highest identity to adiponectin in globular domain (Wong et al., 2009). The structure o

• In an attempt to complete the overview of

  2024-08-01

  

  In an attempt to complete the overview of resistance mechanisms in Spanish codling moth populations, the aims of the present work were to assess the actual occurrence of AChE and kdr mutations in codling moth field populations from different pome fruit-growing areas of Spain, concurrently with the f

• During years research efforts at Los Alamos National Laborat

  2024-08-01

  

  During 2002–2004years research efforts at Los Alamos National Laboratory (LANL) focused on constructing a quantum computer based on regular arrays build from neutral radical molecules possessing one single unpaired BI-7273 spin. The idea was built on the ability to manipulate individual electron sp

• A rational approach for the design of new steroid

  2024-07-31

  

  A rational approach for the design of new steroid compounds as possible competitive inhibitors of CYP17 include chemical modification at C17 of the enzyme's natural substrates, pregnenolone (1) and progesterone (2), introducing groups with moderate to strong dipole properties at C20, such as oxime a

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