• The GSTP promoter region in PCA cells without or with

  2022-07-13

  

  The GSTP1 promoter region in PCA cells without or with reduced GSTP1 mRNA expression had a different histone modification pattern than BPH-1 cells with GSTP1 mRNA expression: the repressive histone modifications H3K9me3/H3K27me2 were distinctly increased and H3K27me3/H3K9me2 were slightly decreased

• Nitrosylation mediated post translational modifications of p

  2022-07-13

  

  Nitrosylation-mediated post-translational modifications of proteins through GSNOR play critical roles in modulating plant defense responses to diverse abiotic and biotic stresses (Frungillo et al., 2013, Leterrier 2011). As the most fundamental and intricate physiological process of plants, photosyn

• Waldeck Weiermair et al demonstrated that in endothelial cel

  2022-07-13

  

  Waldeck-Weiermair et al. (2008) demonstrated that in endothelial cells, the activation of GPR55 by application of 10µM anandamide resulted in a marked increase of ERK1/2 phosphorylation that was evident 2min following drug activation and was sustained for up to 3h. Another example comes from our unp

• siRNA construction and transfection For small interfering RN

  2022-07-13

  

  siRNA construction and transfection. For small interfering RNA (siRNA) experiments, we used Stealth™ select RNAi oligonucleotides targeted against GPR120 (Gibco/Invitrogen). The target sequence of siGPR120 used were; sense 5′-AAGUGGGUGCGAUUGACUUGGUCCA-3′ and antisense 5′-UGGACCAAGUCAAUCGCACCCACUU-3′

• In addition to their functional activation

  2022-07-13

  

  In addition to their functional activation of GPR109A, compounds of the pyrazolopyrimidine class also enhanced the binding of nicotinic Colchicine to the receptor. For instance, increased the binding of H-nicotinic acid to the receptor (black curve) in a concentration-dependent manner, whereas unl

• tranylcypromine australia The biological activity at GPR a

  2022-07-13

  

  The biological activity at GPR109a of each of the 4-functionalized-5-alkyl-pyrazole-3-carboxylic acids (–) was measured using a cAMP whole cell Dynamic2 Homogenous Time-Resolved Fluorescence (HTRF) assay (). Twelve compounds were found to exhibit an EC below 1μM, and of these seven exhibited EC valu

• To further investigate its role in stresses tolerance OsGly

  2022-07-13

  

  To further investigate its role in stresses tolerance, OsGly I was overexpressed in transgenic rice. qRT-PCR and zymologic determination showed that protein kinase g level of OsGly I and the glyoxalase I activity were significantly increased to different extent in the transgenic overexpression line

• br Acknowledgments This work was supported

  2022-07-13

  

  Acknowledgments This work was supported by the Russian Foundation for Basic Research [grant number 16-04-00205], The Russian Science Foundation [grant number 16-15-00235], Czech Academy of Sciences [grant number RVO 61388963], and the Technology Agency of the Czech Republic [grant number TE010200

• In this study we examined whether

  2022-07-13

  

  In this study, we examined whether zebrafish ionocytes might also share other types of similarity in transport function with kidney cells. In addition to ion transport, mammalian kidney GSK 5959 also play key roles in xenobiotic elimination, through the action of ATP-Binding Cassette (ABC) transpor

• br Conclusion Until recently astrocytes were recognized sole

  2022-07-13

  

  Conclusion Until recently, astrocytes were recognized solely for their maintenance role in the regulation of cyp450 inhibitors homeostasis. Nowadays, this idea has changed, it is clear that these cells play a crucial role in the regulation of neuronal activity and signal transmission. In particu

• In the present study compared to diabetic control rats

  2022-07-13

  

  In the present study, compared to diabetic control rats, hepatic glucose-6-phosphatase activity was significantly decreased in both SE and METF treated diabetic animals, with the latter producing greater reduction in glucose-6-phosphatase activity. This observation is consistent with the claim of Ta

• br Materials and methods br Contributors br Acknowledgements

  2022-07-13

  

  Materials and methods Contributors Acknowledgements This work was funded by the Ministry of Human Resources and Social Security, Shanxi Province [(2010)255], by a Shanxi Scholarship Council of China, and supported by a grant from the Alzheimer Society UK. The authors declare no conflict of

• In summary our findings provide the evidence

  2022-07-13

  

  In summary, our findings provide the evidence and the mechanistic understanding of the protective effects of GIP receptor agonist, D-Ala2GIP, in the MPTP-induced neurotoxicity in mice. The observed protective effects are potentially due to reduced oxidative stress and attenuation of dopamine loss in

• The normal function of the FBPase enzyme

  2022-07-12

  

  The normal function of the FBPase enzyme is to catalyze the hydrolysis of F1,6BP to F6P. This activity is induced by diabetes and starvation and is increased in diabetic rats. The level of FBPase can be normalized by insulin, however, similar information is not available from diabetic patients. FBPa

• PKC potentiates insulin release in beta cells however it is

  2022-07-12

  

  PKC potentiates insulin release in beta cells; however, it is currently not clear how this is mechanistically accomplished in living jasplakinolide [15]. First, we discuss PKC structure, regulation, and activation in beta cells. Then, we address two fundamental questions: (1) what is the specific e

14816 records 377/988 page Previous Next First page 上5页 376377378379380 下5页 Last page