• br Methods br Results br Discussion In this series of

  2021-10-16

  

  Methods Results Discussion In this series of studies we hypothesized that FHH-GHSRm1/Mcwi rats would, relative to their WT counterparts, exhibit a metabolic and behavioral phenotype reminiscent of GHSR−/− mice. Through the use of the GHSR−/− mouse, a great deal about the role of ghrelin sig

• br Declaration of competing interests br

  2021-10-15

  

  Declaration of competing interests Acknowledgements The authors wish to thank the Natural Science Foundation of Jiangsu Province (BK20171261), the project of outstanding scientific and technological innovation group of Jiangsu Province, the National Science Fund for Distinguished Young Scholar

• While considering the molecular pathogenesis

  2021-10-15

  

  While considering the molecular pathogenesis of an MPNST, the Ras/Raf/MEK/ERK, mTOR/AKT, p53, and PTEN pathways associated with tumor growth have been described (McCubrey et al., 2012). The involvement of receptor tyrosine kinases such as EGFR and TAM receptor families, and its associated molecular

• Introduction Histamine Imidazolyl ethylamine is an important

  2021-10-15

  

  Introduction Histamine [2-(4-Imidazolyl)-ethylamine] is an important mediator of many physiological and pathological processes including inflammation, gastric poly ic secretion, neuromodulation, regulation of immune function, cell proliferation and differentiation, among others. Histamine exerts i

• br Experimental br Results br Discussion

  2021-10-15

  

  Experimental Results Discussion In this study, we performed molecular docking analysis and in vitro studies to determine whether genistein binds to HIF-1α in BC L 012 sodium salt and identify the residues involved in this interaction. We found that some functional groups (residues) mimic th

• br Materials and methods br

  2021-10-15

  

  Materials and methods Results Discussion In this report, we have analyzed the function of an orphan GPCR, and GPR84, using genetically-deficient mice. The expression of GPR84 in the T and RP 67580 in the spleen prompted us to examine the functional responses of these cells under in vitro a

• The opposite modulation observed for circulating LPI

  2021-10-15

  

  The opposite modulation observed for circulating LPI levels and WAT GPR55 salinomycin mg by nutritional status suggests that increased levels of LPI may down-regulate the expression of its receptor in WAT, whereas in conditions of low serum LPI levels, the expression of GPR55 is stimulated. However,

• As disclosed in our preceding paper medicinal

  2021-10-15

  

  As disclosed in our preceding paper, medicinal chemistry SAR optimization of an HTS hit led to the discovery of , a potent and selective GPR119 agonist. This scaffold differs significantly from the ‘classical’ GPR119 pharmacophore, exemplified by the examples and (). Notably, fluorescent probes lac

• br Methods br Results br Discussion

  2021-10-15

  

  Methods Results Discussion LPD, in terms of insufficient secretion of progesterone by the CL, reflected by low serum progesterone levels can occur in IVF attempts using any kind of ovarian stimulation protocol (Fatemi et al., 2007, Garcia et al., 1981, Van der Linden et al., 2011). However,

• The amyloid precursor protein APP is a

  2021-10-15

  

  The amyloid precursor protein (APP) is a membrane protein thought to be involved in plasticity, synapse formation and repair, and export of metal ions [68]. The APP present in the brain can be cleaved by three different secretases [73], [74]. Cleavage of APP first by alpha secretase and then gamma-s

• No other lacZ mutant showed a marked

  2021-10-15

  

  No other lacZ mutant showed a marked difference in mutation rate between fpg and fpg backgrounds (that is, rates were comparable between HS101 and CSH1191, HS102 and CSH1192, etc.). The number of reversion mutants was much higher in HS1194 than in any other fpg strain. The inclusion of the pTRC99a p

• Ubiquitination of GlyRs subunit on plasma membrane

  2021-10-15

  

  Ubiquitination of GlyRs-α1 subunit on plasma membrane has been shown to initiate the receptor PFI 3 mg and subsequent degradation in lysosomes (Buttner et al., 2001). However, the specific E3 ligase responsible for GlyRs-α1 ubiquitination is largely unknown as yet. Also, the functional consequence

• Introduction Histamine was generally accepted as a neurotran

  2021-10-15

  

  Introduction Histamine was generally accepted as a neurotransmitter in 1984, when histamine was first identified to be located in tuberomamillary nucleus (TM) of the brain (Watanabe et al., 1984). In mammals, histaminergic neurons play an important role in regulating multiple physiological activit

• In spite of the similarities of caffeine s effects in

  2021-10-15

  

  In spite of the similarities of caffeine's effects in L929 cells and erythrocytes, a major difference can be identified in the magnitude of inhibition (35% versus 90%). It initially seems reasonable to conclude from this finding that the reduced magnitude of caffeine inhibition in L929 cells is simp

• In teleosts GR is expressed in almost every cell

  2021-10-15

  

  In teleosts, GR is expressed in almost every cell and regulates genes controlling development, metabolism, and immune response [17,18]. Several teleosts contain two GR genes, GR1 and GR2 [8]. Other groups have found only one GR in some species thus far, such as the Japanese flounder, brown trout, an

14827 records 548/989 page Previous Next First page 上5页 546547548549550 下5页 Last page